The motive behind this Guest lecture for the students of BCA was to enhance the technical skills in the field of Python& Data science to build their career for the future development.It also add values to students to learn the latest technologies which is over and above their curriculum. Approx. 300+ students of BCA( Iyr-142,IIyr-119,IIIyr-66) attended the guest lecture by Mr. Nitin Shrivastav, a Data Scientist in the field of Machine Learning, He spoke on the topic “Application of Python in Data Science” explaining about overview of the Python and start the session with practical implementation of Python using Jupitor tool . He discussed about the use of Python in IOT, Big Data and how it is easy to understand and to implement. Further, he implement a practical scenario of correlation, regression using Python and also used queries to analyze the data. Then he discussed about the Mathematical model and graphical model of Python for clear understanding of the topic. The session was interactive and many students asked questions related to the carrier in the field of Python and also many questions raised with the curiosity to know how to perform the analysis and how we can use the mathematical model, correlation , regression concepts in the Python.